Version: 8.0.0
Date: Tue Jan 28 2025
ina-1
Caenorhabditis elegansWB:WBGene00002081
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ina-1

Species
Caenorhabditis elegans
Symbol
ina-1
Name
INtegrin Alpha 1
Synonyms
  • CELE_F54G8.3
  • F54G8.3
Biotype
protein coding gene
Automated Description
Enables transmembrane signaling receptor activity. Involved in several processes, including cell-cell adhesion mediated by integrin; generation of neurons; and nematode male tail tip morphogenesis. Located in phagocytic cup. Part of integrin complex. Is expressed in several structures, including ABplaapppp; hermaphrodite gonad; neurons; ventral nerve cord; and vulE. Used to study cancer and epilepsy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; junctional epidermolysis bullosa; junctional epidermolysis bullosa with pyloric atresia; and muscular disease. Orthologous to several human genes including ITGA6 (integrin subunit alpha 6).
WB Description
ina-1 encodes one of two C. elegans alpha integrin subunits; during development, ina-1 activity is required for migration of a number of cell types, including neurons, coelomocyte precursors, and the distal tip cells of the somatic gonad; in addition, ina-1 is required for axon fasciculation and morphogenesis of structures such as the head, pharynx, egg-laying apparatus, and male tail; INA-1 coimmunoprecipitates with the PAT-3 beta integrin subunit suggesting that, in vivo, INA-1 and PAT-3 function as a heterodimer to regulate cell migration and tissue morphogenesis; INA-1 is expressed in many tissues, including neurons, the gonad, and the pharyngeal basement membrane; expression begins during gastrulation and continues through to adulthood.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23220
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ina-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              ina-1 role
              ina-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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