Gene

inx-16

Species
Caenorhabditis elegans
Symbol
inx-16
Name
INneXin 16
Synonyms
  • CELE_R12E2.5
  • opu-16
Biotype
protein coding gene
Automated Description
Predicted to enable gap junction hemi-channel activity. Involved in calcium-mediated signaling; regulation of defecation rhythm; and regulation of neuromuscular synaptic transmission. Located in gap junction. Is expressed in intestine.
WB Description
inx-16 encodes a pannexin, an integral transmembrane channel protein that is a structural component of gap junctions; inx-16 is required for the initiation and propagation of the intestinal calcium wave that is essential for proper execution of the C. elegans rhythmic defecation motor program; in addition, inx-16 mutant animals are aldicarb-resistant, suggesting regulatory communication between the intestine and acetylcholine motor neurons; INX-16 is expressed in the intestine where it localizes to points of cell-cell contact, coincident with sites of gap junctions.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11893
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
4.1625M4.1630M4.1635M4.1640M4.1645M4.1650M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions