Gene

iars-1

Species
Caenorhabditis elegans
Symbol
iars-1
Name
Isoleucyl Amino-acyl tRNA Synthetase 1
Synonyms
  • CELE_R11A8.6
  • irs-1
Biotype
protein coding gene
Automated Description
Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Is expressed in body wall musculature; hypodermis; pharynx; and ventral nerve cord. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1).
WB Description
irs-1 encodes a predicted cytoplasmic isoleucyl-tRNA synthetase (IleRS), an aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-1 activity via RNA-mediated interference (RNAi) results in sterility, embryonic lethality, and slower rates of growth, indicating that IRS-1 is essential for development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42780
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
10.3690M10.3695M10.3700M10.3705M10.3710M10.3715M10.3720M10.3725M10.3730M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions