Gene

itr-1

Species
Caenorhabditis elegans
Symbol
itr-1
Name
Inositol Triphosphate Receptor 1
Synonyms
  • CELE_F33D4.2
  • dec-4
Biotype
protein coding gene
Automated Description
Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode pharyngeal pumping; and sperm ejaculation. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including epithelial cell; ganglia; gonad; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Gillespie syndrome; amyotrophic lateral sclerosis; autosomal dominant cerebellar ataxia (multiple); isolated anhidrosis with normal sweat glands; and type 1 diabetes mellitus. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
WB Description
itr-1 encodes a putative inositol (1,4,5) trisphosphate receptor that affects the defecation cycle and pharyngeal pumping, and also affects ovulation in a pathway downstream of LET-23; interacts with UNC-54 in vivo, and is expressed in the adult intestine, pharynx, excretory cell, germ line, and spermatheca, with limited neuronal expression.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13715
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.676M7.678M7.680M7.682M7.684M7.686M7.688M7.690M7.692M7.694M7.696M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            itr-1 molecule type
            Interactor gene
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              Genetic Interactions

              itr-1 role
              itr-1 genetic perturbation
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