Version: 8.0.0
Date: Tue Jan 28 2025
jac-1
Caenorhabditis elegansWB:WBGene00002175
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

jac-1

Species
Caenorhabditis elegans
Symbol
jac-1
Name
Juxtamembrane domain-Associated Catenin 1
Synonyms
  • CELE_Y105C5B.21
  • Y105C5B.21
Biotype
protein coding gene
Automated Description
Enables cadherin binding activity. Involved in embryonic body morphogenesis; regulation of actin cytoskeleton organization; and regulation of protein localization. Located in adherens junction. Part of catenin complex. Is expressed in head. Human ortholog(s) of this gene implicated in DiGeorge syndrome; anxiety disorder; blepharocheilodontic syndrome 2; major depressive disorder; and schizophrenia. Orthologous to several human genes including ARVCF (ARVCF delta catenin family member).
WB Description
jac-1 encodes the C. elegans p120 catenin orthologue; by homology, JAC-1 is predicted to be a component of the cadherin-catenin complex (CCC); jac-1(RNAi) does enhance embryonic morphogenesis defects produced by weak loss-of-function mutations in hmp-1/alpha-catenin, suggesting that JAC-1 positively regulates cadherin-catenin function in the embryo; JAC-1 likely regulates this function by promoting association between the actin cytoskeleton and the cadherin-catenin complex; a JAC-1 reporter fusion localizes to embryonic adherens junctions in a manner that is dependent upon the presence of HMR-1/cadherin, with which it specifically interacts in the yeast two-hybrid system.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10372
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          jac-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            jac-1 role
            jac-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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