Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in hyp6 and hyp7 syncytium.
WB Description
kin-15 encodes a novel receptor protein tyrosine kinase; like kin-16, with which it is cotranscribed, kin-15 encodes a protein that displays some unusual features, including a very small extracellular domain (50 amino acids) that lacks a cysteine-rich region typical of ligand-binding domains of known receptor tyrosine kinases, an unusual amino acid substitution in the subdomain VI motif, and a lack of typical autophosphorylation sites in the kinase insert and C-terminal domains; a kin-15 reporter is first detected in young L1 larvae in the hyp7 syncytium; later expression is detected in ventral and lateral cells that fuse with hyp7 as well as in the more anterior hyp6 syncytium late in development; this distinct expression pattern suggests that kin-15 may also play a role in development of the hypodermal syncytium and perhaps be involved in cell-cell interactions regulating postembryonic cell fusions.