Version: 8.0.0
Date: Tue Jan 28 2025
laf-1
Caenorhabditis elegansWB:WBGene00002244
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

laf-1

Species
Caenorhabditis elegans
Symbol
laf-1
Name
Lethal And Feminizing 1
Synonyms
  • CELE_Y71H2AM.19
  • Y71H2AM.19
Biotype
protein coding gene
Automated Description
Enables RNA strand annealing activity; identical protein binding activity; and molecular condensate scaffold activity. Involved in several processes, including masculinization of hermaphroditic germ-line; positive regulation of embryonic development; and positive regulation of fertilization. Located in P granule. Is expressed in germ line. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked).
WB Description
laf-1 encodes a DEAD-box RNA helicase; laf-1 is required for embryonic development and sex determination; laf-1 was identified in screens for dominant suppressors of the sterility produced by gain-of-function fem-3 mutations; when homozygous, laf-1 mutations result in embryonic and larval lethality and when heterozygous, feminization of XX and XO animals; reporter gene analyses indicate that wild-type laf-1 activity is required for proper translational repression of tra-2 mRNA via its 3'UTR; when expressed in embryos, LAF-1 localizes predominantly to the cytoplasm with additional localization seen in P granules.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47958
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
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        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          laf-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            laf-1 role
            laf-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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