Involved in several processes, including adherens junction assembly; embryonic digestive tract morphogenesis; and maintenance of epithelial cell apical/basal polarity. Located in basolateral plasma membrane. Is expressed in epithelial cell; nerve ring; rectum; and spermatheca. Orthologous to human SCRIB (scribble planar cell polarity protein).
WB Description
let-413 encodes a protein with strong similarity to human ERBIN, rat DENSIN, Drosophila Scribble and its human ortholog hSCRIB; let-413 is required for the assembly of adherens junctions and for maintenance of the apical distribution of the intestinal terminal web; LET-413 protein is localized to the basolateral region of intestinal and hypodermal epithelial cells.