Gene

let-413

Species
Caenorhabditis elegans
Symbol
let-413
Name
LEThal 413
Synonyms
  • CELE_F26D11.11
  • F26D11.11
Biotype
protein coding gene
Automated Description
Involved in several processes, including adherens junction assembly; embryonic digestive tract morphogenesis; and maintenance of epithelial cell apical/basal polarity. Located in basolateral plasma membrane. Is expressed in epithelial cell; nerve ring; rectum; and spermatheca. Orthologous to human SCRIB (scribble planar cell polarity protein).
WB Description
let-413 encodes a protein with strong similarity to human ERBIN, rat DENSIN, Drosophila Scribble and its human ortholog hSCRIB; let-413 is required for the assembly of adherens junctions and for maintenance of the apical distribution of the intestinal terminal web; LET-413 protein is localized to the basolateral region of intestinal and hypodermal epithelial cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23119
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.9735M7.9740M7.9745M7.9750M7.9755M7.9760M7.9765M7.9770M7.9775M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions