Gene

let-721

Species
Caenorhabditis elegans
Symbol
let-721
Name
LEThal 721
Synonyms
  • C05D11.12
  • CELE_C05D11.12
Biotype
protein coding gene
Automated Description
Predicted to enable electron-transferring-flavoprotein dehydrogenase activity. Predicted to be involved in electron transport chain. Located in mitochondrion. Is expressed in several structures, including excretory cell; gonad; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase).
WB Description
The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10617
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensETFDH9 of 9YesYes   
Mus musculusEtfdh9 of 9YesYes   
Rattus norvegicusEtfdh9 of 9YesYes   
Xenopus tropicalisetfdh9 of 9YesYes   
Danio rerioetfdh9 of 9YesYes   
Drosophila melanogasterEtf-QO9 of 9YesYes   
Saccharomyces cerevisiaeCIR29 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
6.4448M6.4450M6.4452M6.4454M6.4456M6.4458M6.4460M6.4462M6.4464M6.4466M6.4468M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
s2447allele
NC_003281.10:g.6445436C>Tvariant
SNP
  • missense variant
NC_003281.10:g.6445974G>Avariant
SNP
  • intron variant
NC_003281.10:g.6445365C>Tvariant
SNP
  • missense variant
NC_003281.10:g.6445783G>Avariant
SNP
  • synonymous variant
NC_003281.10:g.6445221G>Avariant
SNP
  • missense variant
NC_003281.10:g.6444708C>Tvariant
SNP
  • 3 prime UTR variant
NC_003281.10:g.6446514T>Gvariant
SNP
  • missense variant
NC_003281.10:g.6444719G>Avariant
SNP
  • 3 prime UTR variant
NC_003281.10:g.6445257C>Tvariant
SNP
  • missense variant
Showing 1 - 10 of 24 rows
per page

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
BC4157WB
Showing 1 - 1 of 1 rows
per page

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.4448M6.4450M6.4452M6.4454M6.4456M6.4458M6.4460M6.4462M6.4464M6.4466M6.4468MC05D11.12.1 (let-721)

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

10 interactor genes based on 12 annotations
let-721 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
csr-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:32015436
protein
csr-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34108460
protein
gras-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36809245
protein
lin-53Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:31397537
protein
pgl-3Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26912668
protein
sao-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36323675
protein
sip-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26009280
protein
smo-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34003111
protein
smo-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34003111
protein
spd-5Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:35442950
Showing 1 - 10 of 12 rows
per page

Genetic Interactions

No data available