Version: 8.0.0
Date: Tue Jan 28 2025
let-767
Caenorhabditis elegansWB:WBGene00002891
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

let-767

Species
Caenorhabditis elegans
Symbol
let-767
Name
LEThal 767
Synonyms
  • C56G2.6
  • CELE_C56G2.6
Biotype
protein coding gene
Automated Description
Enables long-chain-fatty-acyl-CoA reductase activity and testosterone dehydrogenase [NAD(P)+] activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; long-chain fatty acid biosynthetic process; and steroid metabolic process. Located in apical cortex and endoplasmic reticulum. Is expressed in hypodermis; intestine; and pharynx. Used to study obesity. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
WB Description
let-767 encodes a steroid dehydrogenase required for embryogenesis, molting, and female reproduction; LET-767 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1; in vitro, LET-767 catalytically converts androstenedione and estrone into testosterone and estradiol, and in vivo probably catalyzes the synthesis of endogeneous steroid hormones from cholesterol; LET-767 is expressed from embryos to adults, and is zygotically expressed in the intestine, but a maternal-effect lethal allele (let-767[s2464]) also exists, indicating that LET-767 is probably also provided maternally; LET-767 is paralogous to STDH-1/-4; some let-767 transcripts are spliced to SL2, indicating that let-767 may belong to an operon with C56G2.7.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43086
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          let-767 molecule type
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            Genetic Interactions

            let-767 role
            let-767 genetic perturbation
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