Version: 8.0.0
Date: Tue Jan 28 2025
lev-1
Caenorhabditis elegansWB:WBGene00002974
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lev-1

Species
Caenorhabditis elegans
Symbol
lev-1
Name
LEVamisole resistant 1
Synonyms
  • acr-1
  • CELE_F09E8.7
Biotype
protein coding gene
Automated Description
Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including inorganic cation transmembrane transport; monoatomic ion transmembrane transport; and regulation of egg-laying behavior. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Is expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; cocaine abuse; congenital myasthenic syndrome (multiple); and lung cancer (multiple). Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
WB Description
lev-1 encodes a non-alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, regulation of egg-laying behavior, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3; a LEV-1::GFP fusion protein is expressed in all body wall muscle cells and a subset of ventral cord motor neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18945
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

      Allele/Variant Symbol
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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            13.1745M13.1750M13.1755M13.1760M13.1765M13.1770M13.1775M13.1780M13.1785M13.1790M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            lev-1 molecule type
            Interactor gene
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              Genetic Interactions

              lev-1 role
              lev-1 genetic perturbation
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