Predicted to enable DNA ligase (ATP) activity. Predicted to be involved in DNA ligation and Okazaki fragment processing involved in mitotic DNA replication. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1).
WB Description
lig-1 encodes a putative ATP-dependent DNA ligase, based on homology; lig-1 may be one of the direct targets of the daf-16 forkhead transcription factor, based on chromatin immunoprecipitation (ChIP) studies.