Gene

lin-13

Species
Caenorhabditis elegans
Symbol
lin-13
Name
abnormal cell LINeage 13
Synonyms
  • C03B8.4
  • CELE_C03B8.4
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of vulval development. Located in nucleus. Is expressed in several structures, including epithelial cell; excretory cell; intestine; nervous system; and reproductive system.
WB Description
lin-13 encodes a large (2248-residue) nuclear protein with multiple zinc fingers of the C2H2 class and a LXCXE retinoblastoma protein-binding motif, that is required for survival through larval development and for negative regulation of vulval fates during postembryonic development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24403
Stringency:
Additional filters to further constrain the results:
No ortholog matching your filter. Please try a less stringent filter.
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
ectopic expression transgene
larval arrest
male mating defective
multivulva
neuronal cell fate specification variant
shortened life span
sterile
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
7.701M7.702M7.703M7.704M7.705M7.706M7.707M7.708M7.709M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
n388allele
Yes
n387allele
Yes
n770allele with one associated variant
point mutation
  • stop gained
Yes
NC_003281.10:g.7701987G>Avariant
SNP
  • synonymous variant
NC_003281.10:g.7704635G>Avariant
SNP
  • synonymous variant
NC_003281.10:g.7705308C>Tvariant
SNP
  • intron variant
NC_003281.10:g.7705508C>Tvariant
SNP
  • synonymous variant
NC_003281.10:g.7706119C>Tvariant
SNP
  • synonymous variant
NC_003281.10:g.7706299C>Avariant
SNP
  • missense variant
NC_003281.10:g.7708142C>Tvariant
SNP
  • missense variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
MT1373WB
MT3025WB
MT3061WB
MT706WB
MT8838WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.701M7.702M7.703M7.704M7.705M7.706M7.707M7.708M7.709MC03B8.4.1 (lin-13)C18H2.4C03B8.5

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

19 interactor genes based on 23 annotations
lin-13 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
gex-3Caenorhabditis elegans
protein
  • two hybrid
PMID:11922622
protein
hda-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34003109
protein
hpl-2Caenorhabditis elegans
protein
  • two hybrid
PMID:16890929
protein
hpl-2Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:16890929
protein
hpl-2Caenorhabditis elegans
protein
  • imaging technique
PMID:16890929
protein
lin-61Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:22412383
protein
mbk-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26912668
protein
mbk-2Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26912668
protein
pals-25Caenorhabditis elegans
protein
  • two hybrid
PMID:36191002
protein
smo-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:19922876
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Genetic Interactions

lin-13 role
lin-13 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
hpl-1Caenorhabditis elegans
unspecified role
genetic interaction
    PMID:16905130
    unspecified role
    hpl-2Caenorhabditis elegans
    unspecified role
    genetic interaction
      PMID:16905130
      unspecified role
      hpl-2Caenorhabditis elegans
      unspecified role
      genetic interaction
        PMID:16890929
        suppressed gene
        n770isw-1Caenorhabditis elegans
        suppressor gene
        genetic suppression
          PMID:21343362
          suppressed gene
          n770mes-2Caenorhabditis elegans
          suppressor gene
          genetic suppression
            PMID:21343362
            suppressed gene
            n770mes-3Caenorhabditis elegans
            suppressor gene
            genetic suppression
              PMID:21343362
              suppressed gene
              n770mes-4Caenorhabditis elegans
              suppressor gene
              genetic suppression
                PMID:21343362
                suppressed gene
                n770mrg-1Caenorhabditis elegans
                suppressor gene
                genetic suppression
                  PMID:21343362
                  enhancer gene
                  n770pha-4Caenorhabditis elegans
                  enhanced gene
                  genetic enhancement
                    PMID:17250823
                    suppressed gene
                    n770sumv-2Caenorhabditis elegans
                    suppressor gene
                    genetic suppression
                      PMID:21343362
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