Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Is expressed in several structures, including epithelial cell; germ line; gonad; hypodermis; and somatic gonad precursor.
WB Description
lin-26 encodes a zinc-finger protein that shares a unique C2H2 motif together with LIR-1, LIR-2, and LIR-3; during development, lin-26 activity is required for proper differentiation of non-neuronal ectodermal cells and the somatic gonad epithelium; LIN-26 is expressed in many different cell types including the rectal rep, somatic gonad, glial, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation.