Version: 8.0.0
Date: Tue Jan 28 2025
lin-40
Caenorhabditis elegansWB:WBGene00003025
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lin-40

Species
Caenorhabditis elegans
Symbol
lin-40
Name
abnormal cell LINeage 40
Synonyms
  • CELE_T27C4.4
  • egr-1
Biotype
protein coding gene
Automated Description
Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within chromatin organization; mitochondrial unfolded protein response; and positive regulation of protein localization to nucleus. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including distal tip cell; intestine; nervous system; pharynx; and somatic cell. Orthologous to several human genes including MTA1 (metastasis associated 1) and MTA3 (metastasis associated 1 family member 3).
WB Description
lin-40 encodes, along with egl-27, one of two C. elegans homologs of human MTA1 (metastasis-associated protein), part of a nucleosome remodeling and histone deacetylation (NURD) complex; lin-40 is an essential gene required for proper vulval cell fate specification and morphogenesis; in addition, lin-40 acts with its paralog, egl-27, in regulating posterior ventral hypodermal cell fate specification and embryonic patterning; targets of lin-40 regulation likely include lin-39, which encodes a homeodomain protein also required for vulval cell fate specification.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10865
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          lin-40 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            lin-40 role
            lin-40 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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