Version: 8.0.0Date: Tue Jan 28 2025
Gene
lin-44
- Species
- Caenorhabditis elegans
- Symbol
- lin-44
- Name
- abnormal cell LINeage 44
- Synonyms
- CELE_E01A2.3
- E01A2.3
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including nematode male tail tip morphogenesis; neuron migration; and positive regulation of cell projection organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including P6.pa; anchor cell; hypodermis; rectal epithelial cell; and tail. Human ortholog(s) of this gene implicated in ectodermal dysplasia (multiple); obesity; oral squamous cell carcinoma; split hand-foot malformation 6; and tooth agenesis. Orthologous to several human genes including WNT10A (Wnt family member 10A); WNT10B (Wnt family member 10B); and WNT11 (Wnt family member 11).
- WB Description
- lin-44 encodes one of five C. elegans Wnt signaling ligands; during development, LIN-44 activity is required non-cell-autonomously for polarity specification of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites; in addition, LIN-44 functions redundantly with MOM-2 and CWN-2 to pattern the P7.p lineage during vulval development; lin-44 expression begins at the 1.5-fold stage of embryogenesis in the posterior hypodermal cells hyp10 and hyp11; during later embryonic stages additional expression in hyp8 and hyp9 is detected; reporter fusions and in situ hybridization studies also reveal weak and inconsistent expression in the anchor cell of the somatic gonad.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12027
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:4126056...4129310 + (3.25 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.