Gene

lars-2

Species
Caenorhabditis elegans
Symbol
lars-2
Name
Leucyl Amino-acyl tRNA Synthetase 2
Synonyms
  • CELE_ZK524.3
  • lrs-2
Biotype
protein coding gene
Automated Description
Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in body wall musculature; intestine; and neurons. Used to study Perrault syndrome. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial).
WB Description
lars-2 encodes the ortholog of human leucyl amino-acyl tRNA synthetase (LARS); in C. elegans, lars-2 is required for normal mitochondrial structure and function, and acts downstream of daf-2 to control lifespan; lars-2 mutants show swollen, disorganized and sometimes fused mitochondria, and live much longer than wild-type worms; a lars-2 GFP translation fusion gene was ubiquitously expressed, with prominent expression in body-wall muscle and neurons and with subcellular localization in the mitochondria; being a tRNA synthetase that charges mitochondrial tRNAs for translation, lars-2 is predicted to specifically compromise mitochondrial electron transport and ATP synthesis, through it's effects on mitochrondrially encoded genes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43740
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.4575M7.4580M7.4585M7.4590M7.4595M7.4600M7.4605M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions