Gene

lst-4

Species
Caenorhabditis elegans
Symbol
lst-4
Name
Lateral Signaling Target 4
Synonyms
  • CELE_Y37A1B.2
  • Y37A1B.2
Biotype
protein coding gene
Automated Description
Enables enzyme binding activity and phosphatidylinositol phosphate binding activity. Involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance. Located in early phagosome. Is expressed in embryonic cell and gonad. Orthologous to several human genes including SNX18 (sorting nexin 18) and SNX33 (sorting nexin 33).
WB Description
lst-4 encodes multiple isoforms of a sorting nexin that are the sole C. elegans members of the SNX9 family of sorting nexins ; activity of the SH3 domain-containing LST-4 isoforms is required for regulation of phagosome maturation during apoptotic cell corpse clearance, specifically for regulating phagosomal fusion with endosomes and lysosomes; LST-4 physically interacts with the DYN-1/dynamin GTPase that is also required for phagosomal maturation; LST-4::GFP reporter fusions localizes to phagosomal surfaces as well as to highly dynamic membrane tubules that extend from phagosomes; murine SNX33 is able to rescue the cell corpse engulfment defects seen in lst-4 mutant animals.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45827
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene
Association
Disease Qualifier
Disease
Evidence
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    Transgenic Alleles

    Models

    Sequence Feature Viewer

    Genome location
    Assembly version
    WBcel235
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    14.061M14.062M14.063M14.064M14.065M14.066M14.067M14.068M14.069M

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    Genetic Interactions