Enables enzyme binding activity and phosphatidylinositol phosphate binding activity. Involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance. Located in early phagosome. Is expressed in embryonic cell and gonad. Orthologous to several human genes including SNX18 (sorting nexin 18) and SNX33 (sorting nexin 33).
WB Description
lst-4 encodes multiple isoforms of a sorting nexin that are the sole C. elegans members of the SNX9 family of sorting nexins ; activity of the SH3 domain-containing LST-4 isoforms is required for regulation of phagosome maturation during apoptotic cell corpse clearance, specifically for regulating phagosomal fusion with endosomes and lysosomes; LST-4 physically interacts with the DYN-1/dynamin GTPase that is also required for phagosomal maturation; LST-4::GFP reporter fusions localizes to phagosomal surfaces as well as to highly dynamic membrane tubules that extend from phagosomes; murine SNX33 is able to rescue the cell corpse engulfment defects seen in lst-4 mutant animals.