Gene

lsy-2

Species
Caenorhabditis elegans
Symbol
lsy-2
Name
Laterally SYmmetric (defective in lateral asymmetry) 2
Synonyms
  • CELE_F49H12.1
  • F49H12.1
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity. Involved in nematode larval development; neuron fate specification; and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including anal region; epithelial system; head; intestine; and nervous system.
WB Description
lsy-2 encodes a novel C2H2 zinc-finger transcription factor that is most closely related to other nematode zinc-finger proteins; during development, lsy-2 is required for the left-right asymmetry of the ASE neurons; specifically, lsy-2 is required in ASEL for regulating the expression of the lsy-6 miRNA that controls the asymmetric expression of guanylyl cyclase chemoreceptors; a LSY-2::GFP reporter fusion is expressed ubiquitously from the 50-cell stage of embryogenesis through adulthood with expression seen in both ASEL and ASER; expression is localized to moving nuclear punctae.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24404
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
2.0900M2.0905M2.0910M2.0915M2.0920M2.0925M2.0930M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions