Laterally SYmmetric (defective in lateral asymmetry) 2
Synonyms
CELE_F49H12.1
F49H12.1
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity. Involved in nematode larval development; neuron fate specification; and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including anal region; epithelial system; head; intestine; and nervous system.
WB Description
lsy-2 encodes a novel C2H2 zinc-finger transcription factor that is most closely related to other nematode zinc-finger proteins; during development, lsy-2 is required for the left-right asymmetry of the ASE neurons; specifically, lsy-2 is required in ASEL for regulating the expression of the lsy-6 miRNA that controls the asymmetric expression of guanylyl cyclase chemoreceptors; a LSY-2::GFP reporter fusion is expressed ubiquitously from the 50-cell stage of embryogenesis through adulthood with expression seen in both ASEL and ASER; expression is localized to moving nuclear punctae.