Version: 8.0.0
Date: Tue Jan 28 2025
lys-1
Caenorhabditis elegansWB:WBGene00003090
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lys-1

Species
Caenorhabditis elegans
Symbol
lys-1
Name
LYSozyme 1
Synonyms
  • CELE_Y22F5A.4
  • Y22F5A.4
Biotype
protein coding gene
Automated Description
Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response. Located in apical part of cell and cytoplasmic vesicle. Is expressed in intestine and neurons.
WB Description
lys-1 encodes a putative lysozyme, whose overexpression increasesresistance to infection by Serratia marcescens; lys-1(RNAi) animals havenormal resistance to S. marcescens, perhaps because of geneticredundancy with the LYS-1 paralogs LYS-2 to -8 and LYS-10; in uninfectedanimals, LYS-1 is expressed in the intestine and in IL1/IL2 neurons,along with a few unidentified head neurons; in intestinal cells, LYS-1localizes to apical vesicles; LYS-1 expression is induced by infectionby Pseudomonas aeruginosa but not S. marcescens; LYS-1 expression ispromoted by DBL-1, TIR-1 and NSY-1, and perhaps also by ELT-2, but notby DAF-16; LYS-1 and its paralogs are more similar to lysozymes from theamoeboid protozoon Entamoeba histolytica than to more familiar ones fromvertebrates.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23208
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            10.2780M10.2782M10.2784M10.2786M10.2788M10.2790M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            lys-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              lys-1 role
              lys-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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