Version: 8.0.0
Date: Tue Jan 28 2025
lys-7
Caenorhabditis elegansWB:WBGene00003096
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lys-7

Species
Caenorhabditis elegans
Symbol
lys-7
Name
LYSozyme 7
Synonyms
  • C02A12.4
  • CELE_C02A12.4
Biotype
protein coding gene
Automated Description
Involved in defense response to other organism. Is expressed in head neurons; intestine; and rectal gland cell.
WB Description
lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; LYS-7 functions in the innate immune response as an antimicrobial enzyme that, by homology, hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; loss of lys-7 activity results in enhanced susceptibility to P. aeruginosa PA14, renders worms susceptible to Cryptococcus neoformans killing, but enhances tolerance to the enteric bacteria Salmonella typhimurium; lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23208
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            3.4816M3.4818M3.4820M3.4822M3.4824M3.4826M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            lys-7 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              lys-7 role
              lys-7 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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