Version: 8.0.0Date: Tue Jan 28 2025
Gene
mca-3
- Species
- Caenorhabditis elegans
- Symbol
- mca-3
- Name
- Membrane Calcium ATPase 3
- Synonyms
- CELE_Y67D8C.10
- cup-7
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; positive regulation of endocytosis; and positive regulation of growth rate. Located in plasma membrane. Is expressed in body wall musculature; coelomocyte; intestine; and nervous system. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; autosomal dominant nonsyndromic deafness 82; and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3).
- WB Description
- mca-3 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-3 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; mca-3 activity is required for coelomoycte endocytosis, normal coordinated locomotion, and embryonic and larval development; in regulating endocytosis, MCA-3 is required specifically in the early stages for recruitment of the endocytic machinery to the plasma membrane; an mca-3::gfp reporter is expressed from embryogenesis through adulthood and seen in body wall muscle, the nervous system, intestine, and coelomocytes; in coelomocytes, an MCA-3::GFP fusion protein localizes to the plasma membrane.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24093
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIV:3103157...3133149 - (29.99 kb)
- Assembly version
- WBcel235
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Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.