Version: 8.0.0
Date: Tue Jan 28 2025
mec-8
Caenorhabditis elegansWB:WBGene00003172
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mec-8

Species
Caenorhabditis elegans
Symbol
mec-8
Name
MEChanosensory abnormality 8
Synonyms
  • CELE_F46A9.6
  • F46A9.6
Biotype
protein coding gene
Automated Description
Predicted to enable mRNA binding activity. Involved in several processes, including hemidesmosome assembly; mechanosensory behavior; and nematode larval development. Located in nucleus. Is expressed in several structures, including head muscle; hypodermis; intestine; nervous system; and vulva. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2).
WB Description
mec-8 encodes a protein with two RNA recognition motifs (RRM); mec-8 is required for proper development of body wall muscle and chemosensory and touch receptor neurons and as a result, for embryonic and larval development, sensory neuron fasciculation, and mechanosensation; MEC-8 functions as an mRNA processing factor whose activity is required for alternative splicing of genes such as unc-52/perlecan, with which it interacts genetically to produce synthetic lethality at the two-fold stage of embryonic elongation; mec-8 mutations also exhibit synthetic lethality with mutations in a number of other genes, including the sym genes and daf-18; mec-8; unc-52 synthetic lethality is suppressed by mutations in smu-1 and smu-2 which both encode homologs of mammalian spliceosome-associated proteins; mec-8 is broadly expressed in the embryo and expressed in hypodermal and neuronal tissues in larvae.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10501
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          mec-8 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            mec-8 role
            mec-8 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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