Version: 8.0.0Date: Tue Jan 28 2025
Gene
mef-2
- Species
- Caenorhabditis elegans
- Symbol
- mef-2
- Name
- related to vertebrate MEF2 transcription factor 2
- Synonyms
- CELE_W10D5.1
- W10D5.1
- Biotype
- protein coding gene
- Automated Description
- Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone deacetylase binding activity. Involved in several processes, including receptor guanylyl cyclase signaling pathway; regulation of acetylcholine secretion, neurotransmission; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anal region; body wall; head; intestine; and odorsensory neurons. Used to study autism spectrum disorder and intellectual disability. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language. Orthologous to several human genes including MEF2A (myocyte enhancer factor 2A); MEF2C (myocyte enhancer factor 2C); and MEF2D (myocyte enhancer factor 2D).
- WB Description
- mef-2 encodes a transcription factor that is the sole C. elegans member of the MEF2 subgroup of MADS box transcription factors; loss of mef-2 activity does not result in a strong visible phenotype, although mef-2 mutant adults are slightly dumpy (Dpy); in vitro, MEF-2 is able to bind a consensus MEF2 DNA binding site and interact with the class II histone deacetylase encoded by C10E2.3 (hda-4/hda-7); mef-2 mRNA is detected at all stages of development and expression of mef-2 reporter gene fusions begins in neurons during late embryogenesis and continues in all tissues throughout postembryonic development; mef-2 mutations do not appear to interact with mutations in other myogenic factors such as hlh-1, hlh-8, pha-1, and unc-120.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11945
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:9095957...9100862 + (4.91 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.