Gene

mel-28

Species
Caenorhabditis elegans
Symbol
mel-28
Name
Maternal Effect Lethal 28
Synonyms
  • C38D4.3
  • CELE_C38D4.3
Biotype
protein coding gene
Automated Description
Enables molecular adaptor activity. Involved in mitotic sister chromatid segregation and nuclear pore complex assembly. Located in kinetochore; nuclear envelope; and nucleoplasm. Part of nuclear pore.
WB Description
mel-28 encodes a large (1,784-residue) protein required for nuclearenvelope assembly; MEL-28 is highly divergent from, but orthologous tohuman AT-hook-containing transcription factor 1 (AHCTF1); MEL-28 isfound in nuclear pore complexes (NPCs) during interphase, kinetochoresearly in mitosis, and chromatin later in mitosis; mel-28 mutants werefirst identified in a screen for genes involved in cell division in theearly embryo; mel-28 mutants or mel-28(RNAi) animals have no (or poorlyvisible) pronuclei and nuclear morphology generally, along with a weakmitotic spindle, aberrant chromatin segregation, and abnormallydistributed nuclear envelope (NE) proteins and NPCs; MEL-28 is neededfor normal localization of LMN-1 and EMR-1, and appears to be a stablestructural component of the NE; maternal MEL-28 is needed for embryonicdevelopment.
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
4.787M4.788M4.789M4.790M4.791M4.792M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions