Gene

mgl-1

Species
Caenorhabditis elegans
Symbol
mgl-1
Name
Metabotropic GLutamate receptor family 1
Synonyms
  • CELE_ZC506.4
  • ZC506.4
Biotype
protein coding gene
Automated Description
Predicted to enable group II metabotropic glutamate receptor activity. Involved in positive regulation of lipid storage. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nerve ring; neurons; and pharyngeal nervous system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; congenital stationary night blindness 1B; and schizophrenia. Orthologous to several human genes including GRM3 (glutamate metabotropic receptor 3).
WB Description
mgl-1 encodes a Group II metabotropic glutamate receptor (OMIM:604099, loss-of-function mutations in mice are associated with defects in long-term depression); by homology, MGL-1 is predicted to function as a pre-synaptic G protein-coupled receptor that, in response to glutamate binding, inhibits adenylyl cyclase activity; loss of mgl-1 activity reduces the excess fat of daf-7 mutants, indicating that mgl-1 plays a role in regulation of fat accumulation; in addition, loss of mgl-1 activity via large-scale RNAi screens indicates that, in C. elegans, MGL-1 is required for normal post-embryonic growth rates; an mgl-1::GFP reporter is expressed in interneurons, motor neurons, and pharyngeal neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24060
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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9.969M9.970M9.971M9.972M9.973M9.974M9.975M9.976M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions