Predicted to enable group II metabotropic glutamate receptor activity. Involved in positive regulation of lipid storage. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nerve ring; neurons; and pharyngeal nervous system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; congenital stationary night blindness 1B; and schizophrenia. Orthologous to several human genes including GRM3 (glutamate metabotropic receptor 3).
WB Description
mgl-1 encodes a Group II metabotropic glutamate receptor (OMIM:604099, loss-of-function mutations in mice are associated with defects in long-term depression); by homology, MGL-1 is predicted to function as a pre-synaptic G protein-coupled receptor that, in response to glutamate binding, inhibits adenylyl cyclase activity; loss of mgl-1 activity reduces the excess fat of daf-7 mutants, indicating that mgl-1 plays a role in regulation of fat accumulation; in addition, loss of mgl-1 activity via large-scale RNAi screens indicates that, in C. elegans, MGL-1 is required for normal post-embryonic growth rates; an mgl-1::GFP reporter is expressed in interneurons, motor neurons, and pharyngeal neurons.