Gene

mps-1

Species
Caenorhabditis elegans
Symbol
mps-1
Name
MiRP K channel accessory Subunit 1
Synonyms
  • C29F5.4
  • CELE_C29F5.4
Biotype
protein coding gene
Automated Description
Enables potassium channel regulator activity and protein serine/threonine kinase activity. Involved in several processes, including hyperosmotic response; mechanosensory behavior; and negative regulation of potassium ion transport. Located in axolemma; dendrite membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in sensory neurons and vulva.
WB Description
mps-1 encodes single-pass transmembrane proteins that are related to the vertebrate KCNE proteins, also known as MinK-related peptides (MiRPs) that associate with, and regulate, pore-forming ion channels; mps-1 is required for the normal function of several neurons and thus for normal body touch sensation, chemotaxis to select molecules, osmotic avoidance, and nose-touch; when assayed in ASER neurons or in tissue culture cells coexpressing C. elegans KVS-1, MPS-1 is able to alter the activity of this potassium-selective channel, suggesting that MPS-1 functions in vivo to regulate KVS-1 activity in neurons in which the two proteins are coexpressed; mps-1 reporter fusions are expressed in the vulva and in several chemosensory and mechanosensory neurons, including the ADF neuron.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12876
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            6.2926M6.2928M6.2930M6.2932M6.2934M6.2936M6.2938M6.2940M6.2942M

            Sequence Details

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            Expression

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            Molecular Interactions

            mps-1 molecule type
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              Genetic Interactions

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