Version: 8.0.0
Date: Tue Jan 28 2025
mpz-1
Caenorhabditis elegansWB:WBGene00003404
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mpz-1

Species
Caenorhabditis elegans
Symbol
mpz-1
Name
Multiple PDZ domain protein 1
Synonyms
  • C52A11.4
  • CELE_C52A11.4
Biotype
protein coding gene
Automated Description
Enables GTPase activating protein binding activity. Located in axon. Is expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human PATJ (PATJ crumbs cell polarity complex component) and MPDZ (multiple PDZ domain crumbs cell polarity complex component).
WB Description
mpz-1 encodes a multi-PDZ domain scaffold protein; mpz-1(RNAi) animals have reduced serotonin (5-HT)-stimulated egg laying unless truncated SER-1 is transgenically expressed in vulval muscle; overexpressed MPZ-1 PDZ domain 10 also reduces SER-1-mediated egg laying; the PDZ domain 10 of MPZ-1 binds the C-terminal PDZ-binding motif (ETFL) of the 5-HT receptor SER-1; MPZ-1 also physically interacts with the RHGF-2 RhoGEF, and may also bind NPR-1 and ZC84.4; MPZ-1 binding enhances SER-1 activity; mpz-1 is expressed in the nerve ring, pharyngeal, body, and tail neurons, as well as body wall and vulval muscles; mpz-1 is coexpressed with ser-1 in three neuron types and vulval muscle; MPZ-1 co-localizes with SNB-1 in neuronal puncta and with RHGF-2 in nerve ring axons; mpz-1 may be translationally regulated by a small upstream open reading frame (uORF).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19964
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            10.740M10.745M10.750M10.755M10.760M10.765M10.770M10.775M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            mpz-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              mpz-1 role
              mpz-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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