Version: 8.0.0
Date: Tue Jan 28 2025
mrp-1
Caenorhabditis elegansWB:WBGene00003407
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mrp-1

Species
Caenorhabditis elegans
Symbol
mrp-1
Name
Multidrug Resistance Protein family 1
Synonyms
  • CELE_F57C12.5
  • F57C12.5
Biotype
protein coding gene
Automated Description
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in dauer larval development; regulatory ncRNA-mediated post-transcriptional gene silencing; and stress response to metal ion. Located in plasma membrane. Is expressed in several structures, including intestine; pharyngeal-intestinal valve; rectal valve cell; seam cell; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC3 (ATP binding cassette subfamily C member 3).
WB Description
mrp-1 encodes an ATP-binding cassette (ABC) transporter most closely related to the multidrug resistance-associated proteins; mrp-1 activity is required for efficient RNA interference (RNAi) of a germline-expressed target, pop-1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24223
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          mrp-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            mrp-1 role
            mrp-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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