Predicted to enable double-strand/single-strand DNA junction binding activity and mismatched DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of DNA repeat elements; and mismatch repair. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2).
WB Description
The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).