Gene

msh-2

Species
Caenorhabditis elegans
Symbol
msh-2
Name
MSH (MutS Homolog) family 2
Synonyms
  • CELE_H26D21.2
  • H26D21.2
Biotype
protein coding gene
Automated Description
Predicted to enable double-strand/single-strand DNA junction binding activity and mismatched DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of DNA repeat elements; and mismatch repair. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2).
WB Description
The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11361
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
3.6945M3.6950M3.6955M3.6960M3.6965M3.6970M3.6975M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions