Version: 8.0.0
Date: Tue Jan 28 2025
mtm-1
Caenorhabditis elegansWB:WBGene00003475
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mtm-1

Species
Caenorhabditis elegans
Symbol
mtm-1
Name
MTM (myotubularin) family 1
Synonyms
  • CELE_Y110A7A.5
  • Y110A7A.5
Biotype
protein coding gene
Automated Description
Enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of engulfment of apoptotic cell and phospholipid dephosphorylation. Located in apical cortex; cytosol; and plasma membrane. Is expressed in several structures, including coelomocyte; hermaphrodite somatic gonadal cell; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B1 and congenital structural myopathy. Orthologous to human MTM1 (myotubularin 1); MTMR1 (myotubularin related protein 1); and MTMR2 (myotubularin related protein 2).
WB Description
mtm-1 encodes a myotubularin lipid phosphatase orthologous to human MTM1, MTMR1, and MTMR2; MTM-1 activity is required for negative regulation of endocytosis and apoptotic cell engulfment; mtm-1(RNAi)suppresses the endocytosis defect seen in animals with mutations in let-512 mutants, which encodes a phosphatidylinositol 3-kinase orthologous to yeast Vps34; MTM-1 localizes to the plasma membrane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10807
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            5.1350M5.1355M5.1360M5.1365M5.1370M5.1375M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            mtm-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              mtm-1 role
              mtm-1 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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