Version: 8.0.0
Date: Tue Jan 28 2025
mtm-6
Caenorhabditis elegansWB:WBGene00003478
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mtm-6

Species
Caenorhabditis elegans
Symbol
mtm-6
Name
MTM (myotubularin) family 6
Synonyms
  • CELE_F53A2.8
  • cup-6
Biotype
protein coding gene
Automated Description
Enables phosphatase binding activity. Involved in several processes, including nematode larval development; phosphatidylinositol metabolic process; and pinocytosis. Located in apical plasma membrane and cytosol. Is expressed in several structures, including anal depressor muscle; coelomocyte; intestinal cell; preanal ganglion; and tail. Used to study centronuclear myopathy. Orthologous to human MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8).
WB Description
mtm-6 encodes a myotubularin lipid phosphatase orthologous to human MTMR6, MTMR7, and MTMR8, that regulates phosphoinositide 3-phosphate levels in vivo and whose mutation blocks endocytosis by coelomocytes; the MTM-6A isoform, which rescues the endocytic defect of mtm-6 mutants, is believed to function as part of a complex with MTM-9 and MTM-6A and is predominantly localized to the coelomocyte cytoplasm, with some localization to the coelomocyte membrane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10807
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            13.348M13.349M13.350M13.351M13.352M13.353M13.354M13.355M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            mtm-6 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              mtm-6 role
              mtm-6 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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