Version: 8.0.0
Date: Tue Jan 28 2025
nhl-2
Caenorhabditis elegansWB:WBGene00003598
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nhl-2

Species
Caenorhabditis elegans
Symbol
nhl-2
Name
NHL (ring finger b-box coiled coil) domain containing 2
Synonyms
  • CELE_F26F4.7
  • F26F4.7
Biotype
protein coding gene
Automated Description
Enables DEAD/H-box RNA helicase binding activity. Involved in positive regulation of development, heterochronic; protein localization to cell cortex; and regulation of establishment of cell polarity. Located in P granule and P-body. Is expressed in several structures, including body wall musculature; germ line; gonad; nervous system; and pharynx. Orthologous to human TRIM45 (tripartite motif containing 45).
WB Description
nhl-2 encodes one of five C. elegans proteins that contain TRIM (tripartite-containing motif; RING, B-box, coiled-coil) and NHL (NCL-1, HT2A and LIN-41) domains; NHL-2 functions together with CGH-1 and in association with the miRSC complex to regulate the efficacy of microRNA-target interactions and hence, gene regulation, during postembryonic development; in addition, nhl-2 mutations suppress embryonic lethal mutations in par-2, suggesting that nhl-2 also plays a role in establishing embryonic polarity; NHL-2 physically interacts with CGH-1 and localizes to cytoplasmic P bodies, mRNA processing bodies.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR25462
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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      Allele Synonyms
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            4.8940M4.8945M4.8950M4.8955M4.8960M4.8965M4.8970M4.8975M4.8980M4.8985M4.8990M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nhl-2 molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              nhl-2 role
              nhl-2 genetic perturbation
              Interactor gene
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              Interactor genetic perturbation
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