Gene

npp-3

Species
Caenorhabditis elegans
Symbol
npp-3
Name
Nuclear Pore complex Protein 3
Synonyms
  • CELE_K12D12.2
  • K12D12.2
Biotype
protein coding gene
Automated Description
Predicted to be a structural constituent of nuclear pore. Involved in several processes, including establishment of mitotic spindle orientation; nuclear pore complex assembly; and positive regulation of nematode male tail tip morphogenesis. Predicted to be located in nucleus. Predicted to be part of nuclear pore inner ring. Is expressed in embryonic cell. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205).
WB Description
npp-3 encodes a nucleoporin that is a homolog of vertebrate Nup205; npp-3 is required for normal nuclear pore complex distribution in the nuclear envelope, nuclear exclusion of large non-nuclear macromolecules, chromatin condensation, proper mitotic spindle orientation, early embryonic viability, body integrity, and locomotion.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR31344
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNUP2057 of 9YesYes   
Mus musculusNup2057 of 9YesYes   
Rattus norvegicusNup2057 of 9YesYes   
Xenopus tropicalisnup2054 of 9YesYes   
Danio rerionup2058 of 9YesYes   
Drosophila melanogasterNup2056 of 9YesYes   
Saccharomyces cerevisiaeNUP1923 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensNUP205
is implicated innephrotic syndrome type 13
  • IAGP
    Showing 1 - 1 of 1 rows
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    Alleles and Variants

    Genome location
    Assembly version
    WBcel235
    Viewer Help
    11.866M11.867M11.868M11.869M11.870M11.871M11.872M11.873M11.874M
    Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_003280.10:g.11873219C>Tvariant
    SNP
    • missense variant
    NC_003280.10:g.11869941C>Tvariant
    SNP
    • missense variant
    NC_003280.10:g.11870693G>Cvariant
    SNP
    • splice region variant
    NC_003280.10:g.11871972T>Avariant
    NC_003280.10:g.11872284C>Tvariant
    SNP
    • synonymous variant
    NC_003280.10:g.11872421G>Avariant
    SNP
    • missense variant
    NC_003280.10:g.11872478G>Avariant
    SNP
    • missense variant
    NC_003280.10:g.11873019T>Avariant
    SNP
    • synonymous variant
    NC_003280.10:g.11868260C>Tvariant
    NC_003280.10:g.11866268C>Tvariant
    Showing 1 - 10 of 135 rows
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    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    WBcel235
    Viewer Help
    11.866M11.867M11.868M11.869M11.870M11.871M11.872M11.873M11.874M

    Sequence Details

    Loading...

    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    11 interactor genes based on 11 annotations
    npp-3 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    ain-1Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:28204614
    protein
    chn-1Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:36027913
    protein
    endu-2Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:37443152
    protein
    glh-1Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:31506335
    protein
    gras-1Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:36809245
    protein
    igdb-2Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:28803967
    protein
    lev-11Caenorhabditis elegans
    protein
    • two hybrid
    PMID:18692475
    protein
    nfki-1Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:32350248
    protein
    par-2Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:26912668
    protein
    sao-1Caenorhabditis elegans
    protein
    • affinity chromatography technology
    PMID:36323675
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    Genetic Interactions

    npp-3 role
    npp-3 genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    unspecified role
    daf-2Caenorhabditis elegans
    unspecified role
    e1370
    genetic interaction
      PMID:18006689
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