Version: 8.0.0
Date: Tue Jan 28 2025
nsy-1
Caenorhabditis elegansWB:WBGene00003822
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nsy-1

Species
Caenorhabditis elegans
Symbol
nsy-1
Name
Neuronal SYmmetry 1
Synonyms
  • ask-1
  • CELE_F59A6.1
Biotype
protein coding gene
Automated Description
Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including AWC; hypodermis; intestine; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to several human genes including MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
WB Description
nsy-1 encodes a MAP kinase kinase kinase (MAP3K) that is orthologous to the mammalian apoptosis signal-regulating kinase (ASK) family of protein kinases; nsy-1 activity is required for chemotaxis, egg laying, pathogen response, and response to anoxia; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; NSY-1 interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11584
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page
      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
      per page

        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
        No records match query. Try removing filters.
        Showing 0 - 0 of 0 rows
        per page

          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

          Loading...

          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          nsy-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
          No records match query. Try removing filters.
          Showing 0 - 0 of 0 rows
          per page

            Genetic Interactions

            nsy-1 role
            nsy-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
            No records match query. Try removing filters.
            Showing 0 - 0 of 0 rows
            per page