Version: 8.0.0
Date: Tue Jan 28 2025
num-1
Caenorhabditis elegansWB:WBGene00003830
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

num-1

Species
Caenorhabditis elegans
Symbol
num-1
Name
NUMb related 1
Synonyms
  • CELE_T03D8.1
  • cka-1
Biotype
protein coding gene
Automated Description
Enables enzyme binding activity and protein domain specific binding activity. Involved in endocytic recycling; phospholipid transport; and protein targeting to membrane. Located in basolateral plasma membrane and cytoplasm. Is expressed in several structures, including alimentary muscle; hermaphrodite gonad; nerve ring; pseudocoelom; and rectal valve cell. Orthologous to human NUMB (NUMB endocytic adaptor protein) and NUMBL (NUMB like endocytic adaptor protein).
WB Description
num-1 encodes two isoforms of an ortholog of Drosophila NUMB that inhibits endocytotic recycling and antagonizes RME-1 in vivo; NUM-1 is required for recycling (but not internalization) of a transmembrane endocytosis marker; num-1(bc365) null mutants, while mostly normal, no longer require RME-1 in endocytotic recycling; NUM-1A is localized to the basolateral surfaces of most polarized epithelial cells, such as those in hypodermis and intestine; NUM-1A and -1C isoforms are expressed in many somatic cells in all stages of development, with notable expression in the embryonic intestinal primordium and differentiating epithelia, and (later, through larval to adult stages) in intestine, pharynx, hypodermis, seam cells, coelomocytes, spermatheca, uterus, and head neurons; NUM-1A and -1C are expressed in nuclei, cytoplasmic granules, and cell membranes, being notably concentrated at cell peripheries at lateral cell-cell junctions in early embryos; NUM-1A and -1C are localized to the cell periphery by highly basic N-terminal domains with predicted phosphorylation sites; NUM-1A and -1C isoforms bind PKC-3 via their PTB domains in two-hybrid assays, and may serve as PKC-3 adaptors in vivo; in addition, the NUM-1A PTB also binds the TAT-1C translocase.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11232
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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Other Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            20.830M20.831M20.832M20.833M20.834M20.835M20.836M20.837M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            num-1 molecule type
            Interactor gene
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              Genetic Interactions

              num-1 role
              num-1 genetic perturbation
              Interactor gene
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