Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in hypodermis; male gonad; neurons; and pharynx. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3).
WB Description
old-1 encodes a receptor protein tyrosine kinase; old-1 plays a role in stress resistance and regulation of adult lifespan; Murakami and Johnson showed that old-1 mRNA levels are upregulated in response to stress and in daf-2 and age-1 mutant backgrounds and that overexpression of old-1 in wild-type animals results in extended lifespan and increased resistance to heat and UV irradiation; in contrast, Murphy et al., showed that old-1 expression is downregulated in daf-2 mutants and that old-1(RNAi) in an rrf-3 mutant background slightly extends lifespan; an OLD-1::GFP fusion protein is expressed in the anterior region of worms, in neuronal, hypodermal, and pharyngeal tissues, as well as in the proximal region of the male gonad; expression is visible in young adults and appears to increase as animals age and in response to heat, starvation, or UV irradiation.