Version: 8.0.0
Date: Tue Jan 28 2025
pat-3
Caenorhabditis elegansWB:WBGene00003930
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pat-3

Species
Caenorhabditis elegans
Symbol
pat-3
Name
Paralysed Arrest at Two-fold 3
Synonyms
  • CELE_ZK1058.2
  • epi-2
Biotype
protein coding gene
Automated Description
Predicted to enable integrin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and positive regulation of ovulation. Located in several cellular components, including contractile muscle fiber; focal adhesion; and lateral plasma membrane. Part of integrin complex. Is expressed in several structures, including GABAergic neurons; egg-laying apparatus; enteric muscle; gonad; and vulval precursor cell. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including amelogenesis imperfecta type 1H; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); coronary artery disease (multiple); and leukocyte adhesion deficiency (multiple). Orthologous to several human genes including ITGB1 (integrin subunit beta 1).
WB Description
pat-3 encodes the C. elegans beta-integrin subunit; pat-3 is an essential gene that is required for muscle cell attachment to the overlying hypodermis and for normal muscle filament assembly and function; in addition, pat-3 is required for normal axon guidance and for ovulation; antibody staining reveals that PAT-3 is expressed in body wall muscle as well as in the anal depressor, sphincter, intestinal, vulval, and uterine muscles and the somatic gonad; PAT-3 localizes to dense bodies, M-lines, and intercellular borders.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10082
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            3.9090M3.9095M3.9100M3.9105M3.9110M3.9115M3.9120M3.9125M3.9130M3.9135M3.9140M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            pat-3 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              pat-3 role
              pat-3 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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