Gene

phy-3

Species
Caenorhabditis elegans
Symbol
phy-3
Name
Proline HYdroxylase 3
Synonyms
  • CELE_T20B3.7
  • T20B3.7
Biotype
protein coding gene
Automated Description
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in spermatheca.
WB Description
phy-3 encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (III) isoform (OMIM: 608987). phy-3 belongs to a family of genes coding for catalytic subunits of the collagen modifying enzyme prolyl 4-hydroxylase; PHY-3 is involved in the synthesis of collagens in early embryos; PHY-3 have no obvious phenotypic abnormalities, but the 4-hydroxyproline content of their embryos is markedly reduced; C-P4H activity is only generated when it is coexpressed with another C. elegans PDI isoform; PHY-3 is expressed in the embryos, late larval stages, and adult nematodes, its expression in the larval and adult stages restricted to the spermatheca.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10869
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            16.834M16.835M16.836M16.837M16.838M16.839M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            phy-3 molecule type
            Interactor gene
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              Genetic Interactions

              phy-3 role
              phy-3 genetic perturbation
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