Version: 8.0.0
Date: Tue Jan 28 2025
pkd-2
Caenorhabditis elegansWB:WBGene00004035
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pkd-2

Species
Caenorhabditis elegans
Symbol
pkd-2
Name
human PKD2 (Polycystic Kidney Disease) related 2
Synonyms
  • CELE_Y73F8A.1
  • pdk-2
Biotype
protein coding gene
Automated Description
Enables calcium channel activity. Involved in calcium ion transport; response to hermaphrodite contact; and vulval location. Located in several cellular components, including ciliary membrane; neuronal cell body; and sensory dendrite. Is expressed in nerve ring; neurons; and ray. Used to study autosomal dominant polycystic kidney disease. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to several human genes including PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) and PKD2 (polycystin 2, transient receptor potential cation channel).
WB Description
pkd-2 encodes a TRPP cation channel orthologous to human PKD2; pkd-2 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with lov-1; PKD-2 is expressed in the cilia of three types of male-specific sensory neurons; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10877
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            15.228M15.229M15.230M15.231M15.232M15.233M15.234M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            pkd-2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              pkd-2 role
              pkd-2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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