Version: 8.0.0
Date: Tue Jan 28 2025
tank-1
Caenorhabditis elegansWB:WBGene00004053
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

tank-1

Species
Caenorhabditis elegans
Symbol
tank-1
Name
TANKyrase related 1
Synonyms
  • CELE_ZK1005.1
  • pme-5
Biotype
protein coding gene
Automated Description
Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of programmed cell death; and response to gamma radiation. Located in nucleus.
WB Description
tank-1 (formerly known as pme-5) encodes a protein containing N-terminal ankyrin repeats and C-terminal poly (ADP-ribose) polymerase (PARP) regulatory and catalytic domains that is orthologous to human tankyrase 1 (TNKS; OMIM:603303) and tankyrase 2 (TNKS2; OMIM: 607128), but structurally more similar to the ADPRT-3 tankyrase of Dictyostelium discoideum; TANK-1 also contains a lysine-rich region, a WGR domain, which may mediate DNA interaction, and a coil-coiled region; X-ray-induced apoptosis of germ cells is slightly increased in tank-1(RNAi) animals; DNA damage via ionizing radiation induces tank-1 expression, and this induction absolutely requires HUS-1; TANK-1 is ubiquitously expressed throughout the life cycle, including in the germ line, and localizes to the nucleus.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10459
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            1.277M1.278M1.279M1.280M1.281M1.282M1.283M1.284M1.285M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            tank-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              tank-1 role
              tank-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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