Version: 8.0.0
Date: Tue Jan 28 2025
pod-2
Caenorhabditis elegansWB:WBGene00004076
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pod-2

Species
Caenorhabditis elegans
Symbol
pod-2
Name
Polarity and Osmotic sensitivity Defect 2
Synonyms
  • CELE_W09B6.1
  • phi-47
Biotype
protein coding gene
Automated Description
Predicted to enable acetyl-CoA carboxylase activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; nematode larval development; and polarity specification of anterior/posterior axis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Is expressed in CAN; excretory duct; hypodermis; intestine; and reproductive system. Used to study muscular disease. Orthologous to several human genes including ACACA (acetyl-CoA carboxylase alpha).
WB Description
pod-2 encodes an acetyl-CoA carboxylase; by sequence similarity, POD-2 is predicted to catalyze the first step in de novo fatty acid biosynthesis; pod-2 is required for proper embryonic polarity and for osmotic protection of the eggshell; pod-2 activity is also required for molting.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45728
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          pod-2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            pod-2 role
            pod-2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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