Version: 8.0.0
Date: Tue Jan 28 2025
hgrs-1
Caenorhabditis elegansWB:WBGene00004101
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

hgrs-1

Species
Caenorhabditis elegans
Symbol
hgrs-1
Name
Hepatocyte Growth factor-Regulated TK Substrate (HRS) family 1
Synonyms
  • C07G1.5
  • CELE_C07G1.5
Biotype
protein coding gene
Automated Description
Enables ubiquitin binding activity. Involved in protein localization to non-motile cilium. Located in early endosome and endosome membrane. Part of ESCRT-0 complex. Is expressed in several structures, including coelomocyte; excretory canal; hermaphrodite gonad; intestine; and vulva. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate).
WB Description
hgrs-1 encodes a VHS and FYVE zinc finger-domain containing protein that is the C. elegans ortholog of S. cerevisiae Vps27p and mammalian hepatocyte growth factor-regulated tyrosine kinase substrate (HGS); hgrs-1 activity is essential for molting and thus for proper larval development; consistent with its proposed role in the endocytic pathway, HGRS-1 is also required for proper trafficking of the LRP-1 low-density lipoprotein receptor-related protein 1 and for endosome maturation and regulation of autophagic vesicle accumulation; an HGRS-1::GFP fusion protein is widely expressed, but particularly enriched in epithelial cells; within cells, HGRS-1::GFP localizes to endosomal membranes; HGRS-1 and STAM-1 physically interact in vivo, forming the C. elegans ESCRT-0 complex; on early endosomes; in the context of the complex, both STAM-1 and HGRS-1 bind ubiquitin.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46275
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            hgrs-1 molecule type
            Interactor gene
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              Genetic Interactions

              hgrs-1 role
              hgrs-1 genetic perturbation
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