Gene

hgrs-1

Species
Caenorhabditis elegans
Symbol
hgrs-1
Name
Hepatocyte Growth factor-Regulated TK Substrate (HRS) family 1
Synonyms
  • C07G1.5
  • CELE_C07G1.5
Biotype
protein coding gene
Automated Description
Enables ubiquitin binding activity. Involved in protein localization to non-motile cilium. Located in early endosome and endosome membrane. Part of ESCRT-0 complex. Is expressed in several structures, including coelomocyte; excretory canal; hermaphrodite gonad; intestine; and vulva. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate).
WB Description
hgrs-1 encodes a VHS and FYVE zinc finger-domain containing protein that is the C. elegans ortholog of S. cerevisiae Vps27p and mammalian hepatocyte growth factor-regulated tyrosine kinase substrate (HGS); hgrs-1 activity is essential for molting and thus for proper larval development; consistent with its proposed role in the endocytic pathway, HGRS-1 is also required for proper trafficking of the LRP-1 low-density lipoprotein receptor-related protein 1 and for endosome maturation and regulation of autophagic vesicle accumulation; an HGRS-1::GFP fusion protein is widely expressed, but particularly enriched in epithelial cells; within cells, HGRS-1::GFP localizes to endosomal membranes; HGRS-1 and STAM-1 physically interact in vivo, forming the C. elegans ESCRT-0 complex; on early endosomes; in the context of the complex, both STAM-1 and HGRS-1 bind ubiquitin.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46275
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions