Gene

stam-1

Species
Caenorhabditis elegans
Symbol
stam-1
Name
STAM (Signal Transducing Adapter Molecule) homolog 1
Synonyms
  • C34G6.7
  • CELE_C34G6.7
Biotype
protein coding gene
Automated Description
Enables ubiquitin binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein localization to non-motile cilium; and response to hermaphrodite contact. Located in cilium and early endosome. Part of ESCRT-0 complex. Is expressed in male gonad; neurons; and pharyngeal-intestinal valve. Used to study polycystic kidney disease. Orthologous to several human genes including STAM (signal transducing adaptor molecule).
WB Description
stam-1 encodes a protein containing an N-terminal VSH domain, a central ubiquitin-interacting motif and SH3 domain, and a C-terminal glutamine/asparagine (Q/N)-rich domain that is the C. elegans ortholog of the Janus kinase substrate STAM ('signal-transducing adaptor molecule'); stam-1 is required for maintaining meiotic arrest and for acetylcholine neurotransmission; STAM-1 is required in the germline for arrested oocytes to continue responding to an inhibitory signal from somatic gonadal sheath cells, before the oocytes have been induced by major sperm protein (MSP) to exit meiotic prophase; STAM-1 is located in puncta of the DA motor neurons; STAM-1 and HGRS-1 physically interact in vivo, forming the C. elegans ESCRT-0 complex on early endosomes; in the context of the complex, both STAM-1 and HGRS-1 bind ubiquitin.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45929
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.9025M5.9030M5.9035M5.9040M5.9045M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            stam-1 molecule type
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              Genetic Interactions

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