Version: 8.0.0
Date: Tue Jan 28 2025
ptp-3
Caenorhabditis elegansWB:WBGene00004215
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ptp-3

Species
Caenorhabditis elegans
Symbol
ptp-3
Name
Protein Tyrosine Phosphatase 3
Synonyms
  • C09D8.1
  • CELE_C09D8.1
Biotype
protein coding gene
Automated Description
Enables protein tyrosine phosphatase activity. Involved in several processes, including embryonic morphogenesis; nervous system development; and neuroblast migration. Located in adherens junction and synapse. Is expressed in body wall musculature; embryonic cell; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in coronary artery disease; diabetes mellitus; hyperinsulinism; hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including PTPRD (protein tyrosine phosphatase receptor type D) and PTPRF (protein tyrosine phosphatase receptor type F).
WB Description
ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19134
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ptp-3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            ptp-3 role
            ptp-3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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