Gene

rab-10

Species
Caenorhabditis elegans
Symbol
rab-10
Name
RAB family 10
Synonyms
  • CELE_T23H2.5
  • gum-1
Biotype
protein coding gene
Automated Description
Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including endocytic recycling; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and presynaptic dense core vesicle exocytosis. Located in several cellular components, including Golgi medial cisterna; cholinergic synapse; and cytoplasmic vesicle. Is expressed in several structures, including PVD; coelomocyte; hermaphrodite gonad; hypodermis; and somatic nervous system. Orthologous to human RAB10 (RAB10, member RAS oncogene family).
WB Description
rab-10 encodes a Rab-like GTPase that is a member of the Ras superfamily of small GTPases; RAB-10 is required, upstream of RME-1, for basolateral endocytic recycling in the intestine, but not in oocytes or coelomocytes; RAB-10 is also required for GLR-1 receptor recycling in interneurons; a RAB-10::GFP fusion protein is widely expressed and in the intestine, localizes to early endosomes and the Golgi.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47980
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
dendrite development variant
endocytic recycling compartment organization and biogenesis defective
endocytic transport defect
intestinal vacuole
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
6.4574M6.4576M6.4578M6.4580M6.4582M6.4584M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
q373allele
Yes
ok1494allele
Yes
tm2992allele
wy787allele with one associated variant
point mutation
  • missense variant
Yes
dx2allele with one associated variant
point mutation
  • stop gained
Yes
NC_003279.8:g.6457730G>Avariant
SNP
  • intron variant
NC_003279.8:g.6457757G>Avariant
SNP
  • intron variant
NC_003279.8:g.6457536C>Tvariant
SNP
  • intron variant
NC_003279.8:g.6457822C>Tvariant
SNP
  • splice region variant
NC_003279.8:g.6458379C>Tvariant
SNP
  • missense variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Caenorhabditis eleganspwIs214
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Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
RT17WB
RT2WB
VC1026WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.4574M6.4576M6.4578M6.4580M6.4582M6.4584M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

17 interactor genes based on 23 annotations
rab-10 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
act-5Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36261024
protein
cnt-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:22869721
protein
cnt-1Caenorhabditis elegans
protein
  • two hybrid
PMID:22869721
protein
eat-17Caenorhabditis elegans
protein
  • two hybrid
PMID:23100538
protein
ehbp-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:22869721
protein
ehbp-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:27272733
protein
hum-2Caenorhabditis elegans
protein
  • two hybrid
PMID:19879147
protein
let-413Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:29079669
protein
nhr-49Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:35585236
protein
smo-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34003111
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Genetic Interactions

rab-10 role
rab-10 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressed gene
q373cav-2Caenorhabditis elegans
suppressor gene
genetic suppression (partial)
    PMID:19158391
    suppressor gene
    dhc-1Caenorhabditis elegans
    suppressed gene
    or195
    genetic suppression
      PMID:17676955
      suppressor gene
      dhc-1Caenorhabditis elegans
      suppressed gene
      or283
      genetic suppression
        PMID:17676955
        suppressor gene
        dhc-1Caenorhabditis elegans
        suppressed gene
        or352
        genetic suppression
          PMID:17676955
          suppressed gene
          drr-2Caenorhabditis elegans
          suppressor gene
          genetic suppression
            PMID:20456299
            unspecified role
            hpl-2Caenorhabditis elegans
            unspecified role
            ok917
            synthetic genetic interaction
              PMID:17417969
              unspecified role
              lin-35Caenorhabditis elegans
              unspecified role
              n2239
              synthetic genetic interaction
                PMID:17417969
                unspecified role
                lin-15BCaenorhabditis elegans
                unspecified role
                n744
                synthetic genetic interaction
                  PMID:17417969
                  unspecified role
                  rab-8Caenorhabditis elegans
                  unspecified role
                  synthetic genetic interaction
                    PMID:16884526
                    unspecified role
                    q373rab-8Caenorhabditis elegans
                    unspecified role
                    synthetic genetic interaction
                      PMID:20573983
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