Gene

rab-10

Species
Caenorhabditis elegans
Symbol
rab-10
Name
RAB family 10
Synonyms
  • CELE_T23H2.5
  • gum-1
Biotype
protein coding gene
Automated Description
Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including endocytic recycling; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and presynaptic dense core vesicle exocytosis. Located in several cellular components, including Golgi medial cisterna; cholinergic synapse; and cytoplasmic vesicle. Is expressed in several structures, including PVD; coelomocyte; hermaphrodite gonad; hypodermis; and somatic nervous system. Orthologous to human RAB10 (RAB10, member RAS oncogene family).
WB Description
rab-10 encodes a Rab-like GTPase that is a member of the Ras superfamily of small GTPases; RAB-10 is required, upstream of RME-1, for basolateral endocytic recycling in the intestine, but not in oocytes or coelomocytes; RAB-10 is also required for GLR-1 receptor recycling in interneurons; a RAB-10::GFP fusion protein is widely expressed and in the intestine, localizes to early endosomes and the Golgi.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47980
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.4574M6.4576M6.4578M6.4580M6.4582M6.4584M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions