Version: 8.0.0
Date: Tue Jan 28 2025
ran-2
Caenorhabditis elegansWB:WBGene00004303
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ran-2

Species
Caenorhabditis elegans
Symbol
ran-2
Name
associated with RAN (nuclear import/export) function 2
Synonyms
  • C29E4.3
  • CELE_C29E4.3
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in intestinal cell. Orthologous to human RANGAP1 (Ran GTPase activating protein 1).
WB Description
ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24113
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ran-2 molecule type
          Interactor gene
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            Genetic Interactions

            ran-2 role
            ran-2 genetic perturbation
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            Interactor role
            Interactor genetic perturbation
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