Gene

ran-2

Species
Caenorhabditis elegans
Symbol
ran-2
Name
associated with RAN (nuclear import/export) function 2
Synonyms
  • C29E4.3
  • CELE_C29E4.3
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in intestinal cell. Orthologous to human RANGAP1 (Ran GTPase activating protein 1).
WB Description
ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24113
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.9340M7.9345M7.9350M7.9355M7.9360M7.9365M7.9370M7.9375M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions