associated with RAN (nuclear import/export) function 2
Synonyms
C29E4.3
CELE_C29E4.3
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in intestinal cell. Orthologous to human RANGAP1 (Ran GTPase activating protein 1).
WB Description
ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae.