Gene

rbd-1

Species
Caenorhabditis elegans
Symbol
rbd-1
Name
RBD (RNA binding domain) protein 1
Synonyms
  • CELE_T23F6.4
  • T23F6.4
Biotype
protein coding gene
Automated Description
Predicted to enable RNA binding activity. Involved in several processes, including collagen and cuticulin-based cuticle development; positive regulation of growth rate; and vulval development. Located in nucleolus. Orthologous to human RBM19 (RNA binding motif protein 19).
WB Description
rbd-1 encodes an ortholog of S. cerevisiae Mrd1p; RBD-1 is required for processing of 18S rRNA and subsequent formation of the 40S ribosomal subunit, and is essential for normal development; in addition, RBD-1 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation; like PRO-1, -2, and -3, RBD-1's role in ribosome biogenesis suggests a link between biogenesis in the distal sheath and control of cell division in the germ line; RBD-1 localizes to the nucleolus.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23147
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
12.7250M12.7255M12.7260M12.7265M12.7270M12.7275M12.7280M12.7285M12.7290M12.7295M12.7300M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions