Gene

rbx-1

Species
Caenorhabditis elegans
Symbol
rbx-1
Name
yeast RBX (ring finger protein) homolog 1
Synonyms
  • Ce-rbx-1
  • CELE_ZK287.5
Biotype
protein coding gene
Automated Description
Predicted to enable cullin family protein binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intracellular signal transduction; positive regulation of metaphase/anaphase transition of meiotic cell cycle; and sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation. Part of Cul2-RING ubiquitin ligase complex. Is expressed in germ line; gonad; and oocyte. Orthologous to human RBX1 (ring-box 1).
WB Description
The rbx-1 gene encodes an ortholog of the mammalian RING box protein RBX1 (or ROC1), which interacts with several cullins and is a subunit of both the von Hippel-Lindau (VHL) tumor suppressor complex and of the SCF ubiquitin-ligase (E3) complex.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11210
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.6897M9.6898M9.6899M9.6900M9.6901M9.6902M9.6903M9.6904M9.6905M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions