Version: 8.0.0Date: Tue Jan 28 2025
Gene
rnt-1
- Species
- Caenorhabditis elegans
- Symbol
- rnt-1
- Name
- RuNT related 1
- Synonyms
- B0414.2
- CELE_B0414.2
- Biotype
- protein coding gene
- Automated Description
- Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Is expressed in several structures, including body wall musculature; dopaminergic neurons; intestine; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; breast cancer (multiple); carcinoma (multiple); osteochondrodysplasia (multiple); and pancreatic cancer. Orthologous to several human genes including RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3).
- WB Description
- rnt-1 encodes a transcription factor that is the sole C. elegans member of the Runx family of transcriptional regulators; rnt-1 activity is required for several developmental processes, including regulation of hypodermal seam cell proliferation and proper development of the male tail; rnt-1 mutant animals also exhibit a slight reduction in body size which is enhanced by starvation; RNT-1 can physically interact with SMA-4 and regulates, either directly or indirectly, expression of tlp-1 and cki-1, which encode a C2H2 zinc finger and CDK inhibitor, respectively; RNT-1::GFP reporter fusions are expressed in the nuclei of hypodermal seam cells and transiently in body wall muscles; in males, a RNT-1::GFP is expressed in cells derived from the V5, V6 and T lineages that give rise to the sensory rays.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11950
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:5776093...5788611 + (12.52 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.